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Shear Stress-Induced Binding of Large and Unusually Large von Willebrand Factor to Human Platelet Glycoprotein Ibα

✍ Scribed by Feng Li; Chester Q. Li; Joel L. Moake; José A. López; Larry V. McIntire


Book ID
111569714
Publisher
Springer
Year
2004
Tongue
English
Weight
201 KB
Volume
32
Category
Article
ISSN
0090-6964

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## Background and objective: Thrombus formation is initiated by adhesion of the platelet receptor, glycoprotein (gp) ib-ix-v complex, to its adhesive ligand, von willebrand factor (vwf), in the subendothelium or plasma. the vwf-binding domain of gp ib-ix-v is in the gp ibalpha subunit of the comple