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Shc signaling in differentiating neural progenitor cells

✍ Scribed by Conti, Luciano; Sipione, Simonetta; Magrassi, Lorenzo; Bonfanti, Luca; Rigamonti, Dorotea; Pettirossi, Valentina; Peschanski, Marc; Haddad, Bassam; Pelicci, PierGiuseppe; Milanesi, Gabriele; Pelicci, Giuliana; Cattaneo, Elena

Book ID
109831679
Publisher
Nature Publishing Group
Year
2001
Tongue
English
Weight
746 KB
Volume
4
Category
Article
ISSN
1097-6256

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Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interactio