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Negative signaling in B cells: SHIP Grbs Shc

✍ Scribed by Susheela Tridandapani; Todd Kelley; Damon Cooney; Madhura Pradhan; K.Mark Coggeshall

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 385 KB
Volume: 18
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(97)01112-2

No coin nor oath required. For personal study only.

✦ Synopsis

Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcy receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of Shc with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.

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