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Sharpless Asymmetric Dihydroxylation on an Industrial Scale

✍ Scribed by Ahrgren, Leif; Sutin, Lori


Book ID
117999990
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
85 KB
Volume
1
Category
Article
ISSN
1083-6160

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Novel synthesis of CP-734432, an EP4 ago
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A novel and efficient asymmetric route to CP-734432, a lactam analog of PGE2, that shows selective agonism against the EP4 receptor subtype, is reported herein. The key steps include a Heck coupling to introduce the aryl ring at C-16 and a highly diastereoselective Sharpless asymmetric dihydroxylati