A caveat on the Sharpless asymmetric dihydroxylation
β Scribed by Makoto Iwashima; Takeshi Kinsho; Amos B. Smith III
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 210 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
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followed except acetone'water iis solvent and NMO were used. The reaction mixture contained a small amount of OsO, in t-BuOH (2.5% solution. 13 pL, 0.01 equiv based on olefin), the ligand (0.0025 g, 0.025 equiv), N M O (0.022 g, 1.5 equiv), and tetraethylammonium acetate tetrahydrate (0.033 g, 1 0 e
An improved synthesis of the northern hemisphere of epothilone A is described. This approach utilizes the Sharpless asymmetric dihydroxylation of 5-hexen-2-one (allyl acetone) to generate the precursor for the Wittig reaction and the subsequent ring closing metathesis reaction (RCM). This strategy a
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