𝔖 Bobbio Scriptorium
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SH2 domains: modulators of nonreceptor tyrosine kinase activity

✍ Scribed by Panagis Filippakopoulos; Susanne Müller; Stefan Knapp

Book ID
113883285
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
951 KB
Volume
19
Category
Article
ISSN
0959-440X

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✍ Steven E Shoelson 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 1014 KB

Proteins with SH2 or phosphotyrosine binding (PTB) domains bind activated tyrosine kinase receptors and their substrates to propagate signals into cells. Both of the domains recognize phosphotyrosine. Selectivity in these interactions is conferred by short flanking peptide motifs. Therefore, potenti