Growth inhibition by Abl requires an interplay of its SH2 and tyrosine kinase domains

The tyrosine kinase activity of the C-er

The tyrosine kinase activity of the C-erbB-2 gene product (p185) is required for growth inhibition by anti-p185 antibodies but not for the cytotoxicity of an anti-p185-ricin-a chain immunotoxin

✍ Feng Ji Xu; Cinda M. Boyer; Duk Soo Bae; Shu Wu; Marilee Greenwald; Kathy O'Bria 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 657 KB

Our previous studies have demonstrated that 7 of 10 IgG antibodies against distinct epitopes on the extracellular domain of the c-erb6-2 gene product (p185) inhibit the anchorageindependent growth of SKBr3 human breast-cancer cells that overexpress this transmembrane tyrosine kinase growth-factor re