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SGB-017 (ADCI): A Novel Anticonvulsant with a Dual Mechanism of Action

✍ Scribed by Stephen S. Lin; Lucy R. Sun


Book ID
109105482
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
213 KB
Volume
5
Category
Article
ISSN
1080-563X

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## Abstract The tumor‐associated carbonic anhydrase (CA, EC 4.2.1.1) isozyme CA IX is highly overexpressed in many cancer types via the hypoxia inducible factor‐1Ξ± (HIF‐1Ξ±) cascade. Hypoxic tumors expressing CA IX show a poor response to classical chemo‐ and radio‐therapy treatments. CA IX signific