Renal function in 24 patients with-disseminated nonseminomatous testicular carcinoma treated with combination chemotherapy including cis-platinum was examined prospectively. Renal function was monitored by several determinations of glomerular filtration rate (GFR), effective renal plasma flow (ERPF)
Sexual function after surgery and combination chemotherapy in men with disseminated nonseminomatous testicular cancer
โ Scribed by J. M. Nijman; Dr. H. Schraffordt Koops; J. Oldhoff; J. Kremer; D. T. H. Sleijfer
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 391 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-4790
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โฆ Synopsis
Between 1978 and 1982 the sexual functions of 54 patients with a nonseminomatous testicular tumor stage I1 or I11 were assessed before and after treatment with surgery and combination chemotherapy. Two years after completing therapy 54 % of the patients experienced sexual functional disorders. Greatly reduced or absent antegrade ejaculation was reported by 26 patients; 18 of them had been treated with more or less extensive retroperitoneal lymph node dissection, whereas 8 had not. This means that the chemotherapy might be responsible for ejaculatory disorders in 30% of the patients. Only two patients reported a change in the quality of erection; seven patients experienced a decidedly diminished libido, and five patients noticed their orgasm had changed in a negative sense. The appearance of the contralateral testis changed in 21 patients, who showed "atrophy" of this testis. The findings of this study indicate that sexual and ejaculatory disorders in particular are quite common in men treated for a disseminated nonseminomatous testicular tumor. Many of these disorders seem to be owing to causes other than surgical intervention.
๐ SIMILAR VOLUMES
53 patients were treated with cisplatinvinblastine-bleomycin chemotherapy because of advanced nonseminomatous testicular tumor (NSTT). After the chemotherapy, the serum tumor markers were back to normal in 41 patients, of whom 35 were eligible for surgical removal of the residual tumor. In four pati
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