Some effects of combination chemotherapy with cis-platinum on renal function in patients with nonseminomatous testicular carcinoma
✍ Scribed by Sijtze Meijer; Dirk Th. Sleijfer; Nanno H. Mulder; Wim J. Sluiter; Jan Marrink; Heimen Schraffordt Koops; Theo M. Brouwers; Jan Oldhoff; Gjalt K. van der Hem; Enno Mandema
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 490 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Renal function in 24 patients with-disseminated nonseminomatous testicular carcinoma treated with combination chemotherapy including cis-platinum was examined prospectively. Renal function was monitored by several determinations of glomerular filtration rate (GFR), effective renal plasma flow (ERPF) and serum creatinine, and beta-2-microglobulin. A reduction in GFR and ERPF was found at the end of the induction chemotherapy and at six weeks thereafter. Median GFR and ERPF decreased both 23% (P < 0.01). Serum creatinine and beta-2-microglobulin concentrations however did not rise.
It is suggested that under the influence of chemotherapy with platinum the production of creatinine and beta-2-microglobulin is decreased rendering their serum levels unsuitable as parameters of renal function.