𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Severe osteogenesis imperfecta — the role of bisphosphonate therapy

✍ Scribed by L. Wang; M. Au-Yeong; B. Murray; M. Fitzsgibbon; S. van der Kamp; M. J. McKenna

Publisher
Springer-Verlag
Year
2002
Tongue
English
Weight
208 KB
Volume
171
Category
Article
ISSN
1863-4362

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Type I procollagen in the severe non-let
Type I procollagen in the severe non-lethal form of osteogenesis imperfecta
✍ Ruggero Tenni; Giuseppe Cetta; Katharine Dyne; Antonio Rossi; Daniela Quacci; Lu 📂 Article 📅 1988 🏛 Springer 🌐 English ⚖ 727 KB

We have screened type I procollagen synthesized in vitro by skin fibroblasts from several patients with the severe non-lethal form of osteogenesis imperfecta. Cells from one patient synthesized and secreted both normal and a larger amount of abnormal type I procollagen. The abnormal alpha chains are

Deficient expression of the small proteo
Deficient expression of the small proteoglycan decorin in a case of severe/lethal osteogenesis imperfecta
✍ Dyne, Katharine M.; Valli, Maurizia; Forlino, Antonella; Mottes, Monica; Kresse, 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 32 KB 👁 2 views

In osteogenesis imperfecta (01) the effects of mutations in type I collagen genes generally reflect their nature and localization. Unrelated individuals sharing identical mutations present, in general, similar clinical phenotypes. However, in some such cases the clinical phenotype differs. This vari