Prenatal diagnosis of a severe deforming type of osteogenesis imperfecta
โ Scribed by Aylsworth, Arthur S. ;Seeds, John W. ;Guilford, W. Bonner ;Burns, Charles B. ;Washburn, David B.
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 465 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0148-7299
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We have screened type I procollagen synthesized in vitro by skin fibroblasts from several patients with the severe non-lethal form of osteogenesis imperfecta. Cells from one patient synthesized and secreted both normal and a larger amount of abnormal type I procollagen. The abnormal alpha chains are