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Severe constipation in parkinson's disease relieved by botulinum toxin

✍ Scribed by Dr. Alberto Albanese; Giorgio Maria; Anna Rita Bentivoglio; Giuseppe Brisinda; Emanuele Cassetta; Pietro Tonali

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
444 KB
Volume
12
Category
Article
ISSN
0885-3185

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A parkinsonian patient with severe outlet‐type constipation was treated with injection of botulinum toxin into the puborectalis muscle. A total of 30 units (Botox) was injected in two sites. Resting anal pressure, maximum voluntary contraction, and pressure on straining were evaluated before treatment and 4, 8, 12, and 16 weeks afterward. Pressure values declined following treatment, the decline of pressure on straining ending by week 12. Proctography performed 8 weeks after treatment showed improvement in the anorectal angle and evacuation of barium paste. The clinical benefit lasted for ˜12 weeks. The present data show that botulinum toxin is a promising tool for treating outlet‐type constipation in Parkinson's disease.

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