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Several polymorphisms of the glucocorticoid receptor gene (NR3C1) and their associations with bipolar disorder

✍ Scribed by A. Spijker; E. Hoencamp⁎; E. van Rossum; R. de Rijk; J. Haffmans; M. Blom

Book ID: 113666184
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 64 KB
Volume: 107
Category: Article
ISSN: 0165-0327
DOI: 10.1016/j.jad.2007.12.050

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Glucocorticoid (GC) resistance can occur in a number of diseases. It can be either generalized (i.e., familial glucocorticoid resistance) or localized (i.e., asthma). In many cases, a reason for this resistance to steroids lies with mutations or polymorphisms present in the glucocorticoid receptor g