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Several genes in the extended human MHC contribute to predisposition to autoimmune diseases

✍ Scribed by Benedicte A Lie; Erik Thorsby

Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
121 KB
Volume
17
Category
Article
ISSN
0952-7915

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✦ Synopsis

A Lie and Erik Thorsby

Autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, psoriasis and systemic lupus erythematosus, affect approximately 4% of the population in industrialized countries, and are characterized by an immune-mediated destruction of autologous cells and/or tissues. More knowledge is needed to prevent and treat this large group of diseases. Unravelling the genetic predisposing factors is important in this respect, and large research efforts have been initiated to reach this goal. The human MHC, also called the human leukocyte antigen (HLA) complex, is known to harbour major genetic determinants for autoimmune diseases. For several autoimmune diseases certain classical HLA class II and/or class I genes are strongly associated with disease. As a result of recent systematic screening studies additional genes and regions in the MHC, including the extended MHC, are now known to contribute to the predisposition.

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