✦ LIBER ✦

Setup of glycine continuous synthesis by ammonolysis of monochloroacetic acid

✍ Scribed by Catherine Couriol; Henri Fauduet; Catherine Porte; Alain Delacroix

Book ID: 101266455
Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 158 KB
Volume: 11
Category: Article
ISSN: 0895-7533
DOI: 10.1002/(sici)1098-2728(1999)11:1<29::aid-lra4>3.0.co;2-3

No coin nor oath required. For personal study only.

✦ Synopsis

This article describes the continuous production of glycine by catalytic ammonolysis of monochloroacetic acid in an aqueous medium. The synthesis and crystallization of glycine are carried out in a battery of three stirred double-jacketed reactors while temperature and pH values are controlled. The results of the kinetic study allow one to calculate the residence time in each tank for a desired conversion ratio and are first checked with the setup. Then, some parameters (concentration of reagents, regulation of pH, residence time, catalyst) are modified to improve the final yield in crystallized glycine. The best yield resulting from a flow process (96.6%) is better than that resulting from a batch process (93%) and is obtained in the following conditions: the first step is performed at 75ЊC and pH 5.4 with a 10 mol L ‫1מ‬ monochloroacetic acid solution and a 17 mol L ‫1מ‬ ammonia aqueous one with a 0.2 molar ratio of hexamethylenetetramine; the second step is carried out at 75ЊC and pH 8.0; the optimal

📜 SIMILAR VOLUMES

Ammonolysis of Carboxylic Esters Catalyz

Ammonolysis of Carboxylic Esters Catalyzed by Lipases : Synthesis of Fatty Acid Amides

✍ M. C. DE ZOETE; A. C. KOCK-VAN DALEN; F. VAN RANTWIJK; R. A. SHELDON 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB

Synthesis of ( R )-3,4-Diaminobutanoic A

Synthesis of ( R )-3,4-Diaminobutanoic Acid by Desymmetrization of Dimethyl 3-(Benzylamino)glutarate through Enzymatic Ammonolysis

✍ López-García, Mónica; Alfonso, Igancio; Gotor, Vicente 📂 Article 📅 2003 🏛 American Chemical Society 🌐 English ⚖ 70 KB

Clean synthesis of adipic acid catalyzed

Clean synthesis of adipic acid catalyzed by complexes derived from heteropoly acid and glycine

✍ Shuiying Ren; Zhengfeng Xie; Liqin Cao; Xiaopeng Xie; Gaofei Qin; Jide Wang 📂 Article 📅 2009 🏛 Elsevier Science 🌐 English ⚖ 187 KB

Asymmetric synthesis of amino acids by m

Asymmetric synthesis of amino acids by means of catalytic reduction of azlactones of substituted acylaminoacrylic acids Communication 13. Ammonolysis of 4-benzyl-5-oxazolone

✍ L. F. Godunova; E. S. Levitina; E. I. Karpeiskaya; E. I. Klabunovskii; E. D. Lub 📂 Article 📅 1983 🏛 Springer 🌐 English ⚖ 479 KB

Asymmetric synthesis of uncommon α-amino

Asymmetric synthesis of uncommon α-amino acids by diastereoselective alkylations of a chiral glycine equivalent

✍ Kiyoshi Tanaka; Mija Ahn; Yukari Watanabe; Kaoru Fuji 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 669 KB

For the purpose of practical preparations of a variety of enantiomerically pure uncommon ¢x-amino acids, alkylations of the chiral glycine equivalent 5, which possesses axially chiral binaphthol as an auxiliary, with several electrophiles were investigated. The alkylation proceeded smoothly in satis

A simple synthesis of (RS)-[2-2H] glycin

A simple synthesis of (RS)-[2-2H] glycine by the reductive amination of glyoxylic acid

✍ R. H. White 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 167 KB

The synthesis of (RS)-[2-H] glycine by the reduction of a dilute solution of glyoxylic acid in aqueous ammonia by sodium borodeuteride is described. under which the principal side product of the reduction, iminodiacetic acid, is minimized.