Sesquiterpene Lactones from Daucus glaber
✍ Scribed by Amal A. Sallam; Yukio Hitotsuyanagi; El-Sayed S. Mansour; Atallah F. Ahmed; Sahar Gedara; Haruhiko Fukaya; Koichi Takeya
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- German
- Weight
- 271 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
Six new sesquiterpene lactone esters, daucoguaianolactones A–F (1–6), and one new sesquiterpene lactone, daucoeudesmanolactone A (7) were isolated from the leaves and stems of Daucus glaber (Forssk.) Thell., along with the known sesquiterpene lactones talasins A and B and badkhysin. The structures of 1–6 were established on the basis of extensive 1D‐ and 2D‐NMR spectroscopic studies and that of 7 by X‐ray crystallography. Compounds 4, 7, and talasins A and B showed moderate cytotoxicity against P‐388 leukemia cells.
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