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Sesquiterpene Lactone Parthenolide Blocks Lipopolysaccharide-Induced Osteolysis Through the Suppression of NF-κB Activity

✍ Scribed by Kirk Ho Man Yip; Ming H Zheng; Hao Tian Feng; James H Steer; David A Joyce; Jiake Xu


Book ID
111485156
Publisher
American Society for Bone and Mineral Research
Year
2004
Tongue
English
Weight
887 KB
Volume
19
Category
Article
ISSN
0884-0431

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## Abstract The transcription factor nuclear factor‐κB (NF‐κB) has been shown to be constitutively activated in various human malignancies, including leukemia, lymphoma and a number of solid tumors. NF‐κB regulates the transcriptional of genes important for tumor invasion, metastasis and chemoresis