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Sesquiterpene lactone fraction from Artemisia khorassanica inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression through the inactivation of NF-κB

✍ Scribed by Emami, Seyyed Ahmad; Taghizadeh Rabe, Shahrzad Zamnai; Iranshahi, Mehrdad; Ahi, Ali; Mahmoudi, Mahmoud

Book ID: 125539311
Publisher: Informa plc
Year: 2010
Tongue: English
Weight: 794 KB
Volume: 32
Category: Article
ISSN: 0892-3973
DOI: 10.3109/08923971003677808

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## Abstract 4‐hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues and was recently identified as a potent catabolic factor in OA cartilage. In this study, we provide additional evidence that HNE acts as an inflammatory mediator by