Serve, reversible thrombocytopenia associated with meclofenamate

✍ Scribed by Gregory F. Schimizzi; Phillip M. Graehl; Joseph P. Michalski

• Publisher: John Wiley and Sons
• Year: 1982
• Tongue: English
• Weight: 199 KB
• Volume: 25
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780250322

✦ Synopsis

359

indomethacin treatment (26.0 5 15.6%; P < 0.005).

When PBL were obtained from the patient during periods of medication or from the healthy control, in vitro addition of indomethacin did not cause a significant change in generation of Con A-SC. These data showing that the reduced generation of Con A-SC activity during drug-free periods could also be reversed by in vitro addition of indomethacin to the generation cultures indicate that the changes observed in vivo were from the effect of the drug on lymphocyte function and were not a nonspecific manifestation of the clinical improvement. Since in vivo indomethacin treatment of some patients with decreased Con A-SC generation can affect the results of this assay, it is clear that treatment with antiinflammatory drugs must be considered in any study that attempts to relate Con A-SC function to disease activity.

Acknowledgments.