The growth of an epithelial canine kidney line (MDCK) was reversibly arrested by gradually lowering t h e serum concentration in the medium over a 3-day period. The cells were demonstrably quiescent by autoradiography after an additional 24 hours in serum-free media. Addition of fresh serum produced
Serum Stimulates the Na+,K+Pump in Quiescent Fibroblasts by Increasing Na+Entry
β Scribed by Jeffrey B. Smith and Enrique Rozengurt
- Book ID
- 123655358
- Publisher
- National Academy of Sciences
- Year
- 1978
- Tongue
- English
- Weight
- 754 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/68673
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## Abstract Recently, we have found that an increase in the intracellular level of cAMP acts as a mitogenic signal for Swiss 3T3 cells (Rozengurt et al., Proc. Natl. Acad. Sci. USA, 78:4392, 1981). The results presented in this paper demonstrate that addition of cAMPβelevating agents to confluent a