Serum stimulated DNA synthesis in mouse embryo fibroblasts: Synergistic enhancement by staphylococcal lipoteichoic acid
β Scribed by Joe B. Bolen; Jack L. Tribble; Gary L. Smith
- Book ID
- 118877381
- Publisher
- Elsevier Science
- Year
- 1978
- Tongue
- English
- Weight
- 516 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0014-4827
No coin nor oath required. For personal study only.
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Diploid human fibroblasts in culture (WI 38) were allowed to reach a stationary phase and were then stimulated to reenter DNA synthesis and cell division by addition of serum to the culture medium. The rate of protein synthesis increased during the first hours after addition of serum reaching at thr
## Abstract We have recently shown that TNF is produced in liver rapidly after partial hepatectomy and that TNF can stimulate DNA synthesis of hepatocyte primary culture with its inhibition by interleukin 6 and transforming growth factorβΞ², indicating a pivotal role of TNF and TNFβdriven cytokine i