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Serum protein binding of valproic acid and its displacement by palmitic acid in vitro.

โœ Scribed by A. Monks; A. Richens

Book ID
117942141
Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
409 KB
Volume
8
Category
Article
ISSN
0306-5251

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Pharmacokinetic aspects of drug effects
Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture
โœ Constanze Lewandowski; Stephan Klug; Heinz Nau; Diether Neubert ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer-Verlag ๐ŸŒ English โš– 369 KB

Pharmacokinetic studies were performed in connection with culture experiments. Using the technique of cultivating whole rat embryos of the early postimplantation stage, we measured the concentration of valproic acid (VPA) and 2-en-VPA in the culture medium (free and protein-bound form) and in embryo