Serum levels of N-acetylaspartate in Huntington's disease: Preliminary results
β Scribed by Maddalena Ruggieri; Claudia Serpino; Edmondo Ceci; Vittorio Sciruicchio; Giovanni Franco; Carmela Pica; Maria Trojano; Paolo Livrea; Marina de Tommaso
- Book ID
- 102945956
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 838 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0885-3185
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## Abstract Huntington's disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and psychiatric symptoms and by a progressive degeneration of neurons in basal ganglia and in brain cortex. Brainβderived neurotrophic factor (BDNF) is a proβsurvival factor for striatal neurons
## Abstract Aripiprazole (AP), a dopamine (DA) D~2~ receptor partial agonist, has recently been used to reduce schizophrenic symptoms, while tetrabenazine (TBZ), a DA depletor, has been used to treat hyperkinesias in Huntington's disease (HD). The aim of this study is to define the role of AP on ch