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Serum levels of interleukin-2 receptor and disease activity in patients with iga nephropathy

✍ Scribed by Dr. Yasuhiko Tomino; Teruyo Ozaki; Hikaru Koide; Masayoshi Takahashi; Kiichi Ito

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
1005 KB
Volume
3
Category
Article
ISSN
0887-8013

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✦ Synopsis

The levels of serum interleukin-2 receptor (IL-2R) were studied by enzyme-linked immunosorbent assay (ELISA) in patients with IgA nephropathy. The aim of the present study was to determine if levels of serum IL-2R might correlate with disease activity in patients with IgA nephropathy. Twenty-eight patients with IgA nephropathy were examined.

This study showed a significant correlation between the levels of serum IL-2R and disease activities, i.e., levels of urinary protein, blood urea nitrogen (BUN) and uric acid, in patients with IgA nephropathy. The levels of serum IL-2R in patients with moderate or advanced stage of IgA nephropathy were significantly higher than those in patients with the minimal or slight stage of this disease or in healthy adults. It was suggested that the measurement of serum IL-2R is useful in evaluating the degree of disease activity and/or prognosis in patients with IgA nephropathy.

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