## Abstract We examined the correlation among the levels of urinary monocyte chemoattractant proteinβ1 (MCPβ1) and interleukinβ8 (ILβ8), hyperglycemia, and renal injuries in patients with type 2 diabetic nephropathy. The levels of urinary MCPβ1, ILβ8, protein excretion, blood urea nitrogen (BUN), s
Urinary levels of monocyte chemoattractant protein (MCP)-1 and disease activity in patients with IgA nephropathy
β Scribed by Akemi Saitoh; Yusuke Suzuki; Masahiro Takeda; Kiichi Kubota; Kiichi Itoh; Yasuhiko Tomino
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 184 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-8013
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β¦ Synopsis
Using a quantitative sandwich ELISA, we studied 17 patients with IgA nephropathy to determine if levels of urinary monocyte chemoattractant protein-1 (MCP-1) might reflect the disease activity. The levels of urinary MCP-1 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease, or in healthy controls. The results showed a significant correlation between the levels of urinary MCP-1 and the disease activity, i.e., levels of urinary casts and urinary protein. It was thus suggested that the measurement of urinary MCP-1 is useful in evaluating the degree of renal injuries and/or prognosis in patients with IgA nephropathy.
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