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Urinary levels of monocyte chemoattractant protein (MCP)-1 and disease activity in patients with IgA nephropathy

✍ Scribed by Akemi Saitoh; Yusuke Suzuki; Masahiro Takeda; Kiichi Kubota; Kiichi Itoh; Yasuhiko Tomino


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
184 KB
Volume
12
Category
Article
ISSN
0887-8013

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✦ Synopsis


Using a quantitative sandwich ELISA, we studied 17 patients with IgA nephropathy to determine if levels of urinary monocyte chemoattractant protein-1 (MCP-1) might reflect the disease activity. The levels of urinary MCP-1 in patients with the advanced stage were significantly higher than those in patients with the mild stage of the disease, or in healthy controls. The results showed a significant correlation between the levels of urinary MCP-1 and the disease activity, i.e., levels of urinary casts and urinary protein. It was thus suggested that the measurement of urinary MCP-1 is useful in evaluating the degree of renal injuries and/or prognosis in patients with IgA nephropathy.


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