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Serum levels of 8-methoxypsoralen in psoriasis patients using a new fluorodensitometric method

✍ Scribed by M. J. Herfst; E. A. M. Koot-Gronsveld; F. A. Wolff

Publisher: Springer-Verlag
Year: 1978
Tongue: English
Weight: 291 KB
Volume: 262
Category: Article
ISSN: 0340-3696
DOI: 10.1007/bf00455567

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✦ Synopsis

A method is described for the determination of 8-methoxypsoralen in human serum using a fluorodensitometric method. The fluorescence densitometry was carried out directly on the thin layer plate. The developing fluid consisted of chloroform/methanol. In patients with psoriasis after oral application of 8-methoxypsoralen the peak serum levels are mostly found between 2 and 3 h. One milliliter serum is sufficient to determine 8-methoxypsoralen levels. The results are in accordance with those obtained with gas chromatographic methods.

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