## Abstract Recent epidemiological studies have shown that high serum levels of insulinโlike growth factorโI (IGFโI) are associated with an increased risk of lung, colon, breast and prostate cancer. Since very few studies have addressed the role of serum levels of IGFโI in the development of pancre
Serum Insulin-like Growth Factors, Insulin-like Growth Factor-binding Protein-3, and Risk of Lung Cancer Death: A Case-control Study Nested in the Japan Collaborative Cohort (JACC) Study
โ Scribed by Wakai, Kenji ;Ito, Yoshinori ;Suzuki, Koji ;Tamakoshi, Akiko ;Seki, Nao ;Ando, Masahiko ;Ozasa, Kotaro ;Watanabe, Yoshiyuki ;Kondo, Takaaki ;Nishino, Yoshikazu ;Ohno, Yoshiyuki ;,
- Book ID
- 108582111
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2002
- Tongue
- English
- Weight
- 63 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0910-5050
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## Abstract The physical inactivity and obesity involved in hyperglycemia and hyperinsulinemia is supposed to lead to an increased bioavailability of insulinโlike growth factorโI (IGFโI). The carcinogenic effect of IGFโI may be influenced by IGF binding proteins. We investigated the association bet
Insulin-like growth factor-I (IGF-I) has mitogenic and anti-apoptotic properties and has been implicated in the development of breast, colorectum, prostate and lung cancer. IGF binding proteins (IGFBPs) are not only carrier proteins for IGFs but also hold a central position in IGF ligand-receptor in