Tamoxifen alters levels of serum insulin-like growth factors and binding proteins in postmenopausal breast cancer patients: A prospective paired cohort study
β Scribed by Gay-Hui Ho; Chen-Yang Ji; Beng-Hooi Phang; Kok-Onn Lee; Khee-Chee Soo; Eng-Hen Ng
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 1015 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1068-9265
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Background. Insulin-like growth factor I (IGF-I) is a potent mitogen for breast cancer cells. The majority of IGF-I in plasma is bound to IGF binding proteins (IGFBPs), which modulate the biologic effects of IGF-I. Methods. Plasma concentrations of IGF-I, IGFBP-I, and IGFBP-3 were compared between
Insulin-like growth factor-I (IGF-I) has mitogenic and anti-apoptotic properties and has been implicated in the development of breast, colorectum, prostate and lung cancer. IGF binding proteins (IGFBPs) are not only carrier proteins for IGFs but also hold a central position in IGF ligand-receptor in
## Abstract The physical inactivity and obesity involved in hyperglycemia and hyperinsulinemia is supposed to lead to an increased bioavailability of insulinβlike growth factorβI (IGFβI). The carcinogenic effect of IGFβI may be influenced by IGF binding proteins. We investigated the association bet