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Serum hyaluronan (hyaluronic acid) in breast cancer patients

โœ Scribed by Bertrand Delpech; Bernard Chevallier; Nadine Reinhardt; Jean-Pierre Julien; Christian Duval; Catherine Maingonnat; Philippe Bastit; Bernard Asselain

Publisher
John Wiley and Sons
Year
1990
Tongue
French
Weight
283 KB
Volume
46
Category
Article
ISSN
0020-7136

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โœฆ Synopsis

Eighty-three women with breast cancer (57 with systemic metastasis, 26 without) were investigated for serum hyaluronan (HA) and compared to 50 patients with benign diseases of the breast. Hyaluronan was significantly increased in sera of metastatic patients compared to sera of non-metastatic patients (p < 0.OOOl) and also in sera of non-metastatic patients when compared to control sera (p < 0.01). The difference was not related to the number of metastatic sites involved. Three months after starting cytotoxic chemotherapy in metastatic patients, lower H A concentrations were observed in patients responding to chemotherapy. The initial level of serum HA had no predictive value concerning response to chemotherapy*

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