Serum HBsAg, HBeAg, anti-HBe, and hepatitis B viral DNA in asymptomatic carriers in Taiwan

✍ Scribed by Ding-Shinn Chen; Ming-Yang Lai; Sheng-Chung Lee; Jin-Chuan Sheu; Pel-Ming Yang; Juei-Low Sung

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: English
• Weight: 523 KB
• Volume: 19
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.1890190113

✦ Synopsis

Plasma samples from 89 asymptomatic hepatitis B surface antigen (HBsAg) positive volunteer blood donors were titrated for HBsAg by radioimmunoassay using the parallel line method. HBsAg titers ranged widely from 0.01 to 325 pg/ ml. The titers correlated well with hepatitis B viral DNA (HBV DNA) and hepatitis B e antigen (HBeAg) in the serum. The HBsAg titers in 55 HBV DNA positive carriers were 90.7 f 61.7 pg/ml (Mean f SD) vs. 6.3 f 12.2 pglml in the 34 carriers without HBV DNA in the serum. The titers were 93.9 & 59.1 pg/ ml in 56 carriers with HBeAg, 6.4 f 10.1 pg/ml in 24 anti-HBe-positive carriers, and 4.9 f 4.6 pg/ml in 9 HBeAg/anti-HBe-negative carriers. 50 (89.3%) of the 56 HBeAg-positive carriers had HBV DNA, in contrast to four (16.7%) of 24 anti-HBe-positive carriers. The study indicated that high-titered HBsAg carriers were much more likely to be infectious, and confirmed that HBeAg is a practical marker of infectivity. Absence of HBeAg, however, did not exclude infectivity in asymptomatic HBsAg carriers, inasmuch as one-sixth of the carriers had HBV DNA.