Serum granulocyte colony-stimulating factor in patients with repeated infections

✍ Scribed by Mutsumi Kawakami; Hisashi Tsutsumi; Toshiro Kumakawa; Makiko Hirai; Shinichiro Kurosawa; Mayumi Mori; Masafumi Fukushima

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 372 KB
• Volume: 41
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.2830410309

✦ Synopsis

We have already reported significant elevation of serum granulocyte colony-stimulating factor (G-CSF) in the acute phase of infection. In this study, we compared the responses to infection between patients with frequently repeated infection (repeaters) and others (nonrepeaters). We examined the clinical data and serum G-CSF levels in 48 patients with acute infections. Serum G-CSF levels were significantly lower in repeaters than in nonrepeaters (197.7 2 370.0 vs. 1014.1 2 924.4 pg/ml. P < 0.001). There were no significant differences in age, serum total protein, or cholinesterase between the groups, but serum albumin was significantly lower in repeaters than in non-repeaters (2.87 2 0.5 vs.

3.31 2 0.4 g/dl. P < 0.005). It is suggested that administration of recombinant G-CSF may be useful for patients with repeated infections.