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Serum folate and homocysteine levels in head and neck squamous cell carcinoma

✍ Scribed by Giovanni Almadori; Francesco Bussu; Jacopo Galli; Gabriella Cadoni; Bruno Zappacosta; Silvia Persichilli; Angelo Minucci; Bruno Giardina

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 85 KB
Volume: 94
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.10343

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## Abstract Inactivation of the __p16^INK4A^__ (__CDKN2A)__ gene in the Rb pathway is among the most common somatic alterations observed in tobacco‐related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. De