Serum ferritin and total units transfused for assessing iron overload in adults with sickle cell disease
β Scribed by Emma Drasar; Nisha Vasavda; Norris Igbineweka; Moji Awogbade; Marlene Allman; Swee Lay Thein
- Book ID
- 114714643
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 459 KB
- Volume
- 157
- Category
- Article
- ISSN
- 0007-1048
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π SIMILAR VOLUMES
Cerebrovascular accident (CVA) is a major complication of sickle cell disease during childhood. Long-term transfusion reduces the hemoglobin S level and generally prevents recurrent stroke, but it also results in progressive iron overload that requires regular chelation therapy. Erythrocytapheresis
## Abstract A natural history study was conducted in 142 Thalassemic (Thal), 199 transfused Sickle Cell Disease (TxβSCD, __n__ = 199), and 64 nonβTxβSCD subjects to describe the frequency of ironβrelated morbidity and mortality. Subjects recruited from 31 centers in the US, Canada or the UK were si