## Abstract Patients with sickle cell disease (SCD) appear to be at lower risk of endocrinopathies and cardiac dysfunction than those with thalassemia major (TM). Circulating redox active iron is lower in these patients, possibly due to increased systemic inflammation and circulating cytokines. Hep
Disparity in the management of iron overload between patients with sickle cell disease and thalassemia who received transfusions
β Scribed by Ellen B. Fung; Paul R. Harmatz; Meredith Milet; Vinod Balasa; Samir K. Ballas; James F. Casella; Lee Hilliard; Abdullah Kutlar; Kenneth L. McClain; Nancy F. Olivieri; John B. Porter; Elliott P. Vichinsky; the Multi-Center Iron Overload Research Group
- Book ID
- 109144150
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 110 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0372-1248
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π SIMILAR VOLUMES
## Abstract ## Purpose To evaluate the magnetic properties of the spleen in chronically transfused, ironβoverloaded patients with sickle cell disease (SCD) and thalassemia major (TM) and to compare splenic iron burdens to those in the liver, heart, pancreas, and kidneys. ## Materials and Methods
## Abstract A natural history study was conducted in 142 Thalassemic (Thal), 199 transfused Sickle Cell Disease (TxβSCD, __n__ = 199), and 64 nonβTxβSCD subjects to describe the frequency of ironβrelated morbidity and mortality. Subjects recruited from 31 centers in the US, Canada or the UK were si
## Abstract ## BACKGROUND Approximately 15,000 new cases of myelodysplastic syndromes (MDS) are expected in the United States each year. ## METHODS The mainstay for the management of myelodysplastic syndromes (MDS) is supportive therapy with red blood cell (RBC) transfusions to improve the patie