Serum esterase genetics in rabbits. II. Genetic analysis of the prealbumin esterase system, including atropinesterase and cocainesterase polymorphism

✍ Scribed by L. F. M. Zutphen

• Publisher: Springer
• Year: 1974
• Tongue: English
• Weight: 675 KB
• Volume: 12
• Category: Article
• ISSN: 0006-2928
• DOI: 10.1007/bf00485952

✦ Synopsis

The zymotypic variation of rabbit prealbumin esterases is controlled by three autosomal loci, each with two alleles: Est-1 s and Est-1 s, Est-2 v and Est-2 f', Est-3 D and Est-3 d. Est-1 s gives rise to the three S zones possessing the cocainesterase activity, Est-2 v to the three F zones with atropinesterase activity. Presence of the latter allele is never manifested without the Est-1 s allele. Est-3 D codes for the D zone. This D esterase reacts with the currently used substrate ~-naphthylacetate only in the presence of the F zones. Est-1 and Est-2 loci are closely linked (<0.5%o recombination); Est-3 shows no coupling with Est-1 and Est-2. The Est-1 s and Est-3 D alleles have a complete dominant expression, whereas the Est-2 alleles are codominant. Gene frequencies of the Est-1 and Est-2 loci vary between the examined breeds. A Hardy-Weinberg equilibrium is found in two populations (Cpb:ALU and Cpb: VW). A significant surplus of heterozygotes is demonstrated in a third population (Cpb:CH).