Serum alpha1-antitrypsin and haptoglobin phenotypes in vitiligo

✍ Scribed by M. Mujahid Ali; M. Banu; M. A. Waheed; G. S. A. Quadri; C. M. Habibullah

• Publisher: Springer-Verlag
• Year: 1990
• Tongue: English
• Weight: 214 KB
• Volume: 282
• Category: Article
• ISSN: 0340-3696
• DOI: 10.1007/bf00372625

✦ Synopsis

The role of genetic factors in the etiology of vitiligo has been discussed by some workers [5,8], and the familial incidence of vitiligo transmitted by an autosomally dominant gene of variable penetrance has already been established [8]. About 40% of patients report a positive family history of the disease [5]. Dermatoglyphic patterns, such as increased frequency of whorls and arches and decreased total finger ridge count have been associated with vitiligo [5]. In view of the reported genetic markers associated with vitiligo we studied the serum alphal-antitrypsin and haptoglobin (Hp) phenotypes in vitiligo patients to further establish the role of genetic factors in the etiology of this disease.

From the Central Research Institute for Unani Medicine in Hyderabad, 90 vitiligo patients of both sexes, aged between 15 and 40 years (mean age 28.3 • 9.2 years), were selected. The study was conducted in the Depart-