Alpha1-antitrypsin phenotypes in rheumatoid arthritis
β Scribed by Jukka Hietala; Heikki Rantala; Markku Hakala; Olli Koivisto
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 133 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0004-3591
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π SIMILAR VOLUMES
Alpha,-antitrypsin (a-AT) is a protease inhibitor system consisting of more than 30 phenotypic alleles, which can be differentiated by polyacrylamide gel-isoelectric focusing. The most common alleles are designated PiM, Pis, and PiZ. The phenotype MM is found in about 90% of the U.S. white populatio
Recent reports have suggested that the alpha-1-antitrypsin allele Piz, which in homozygotes results in severe deficiency of this important protease inhibitor, is maintained at a relatively high gene frequency through the mechanism of segregation distortion. We report here on 121 nuclear families sel
## Abstract The relationship between the nature and severity of inflammatory eye disease was analyzed with respect to HLA antigens and alpha~1~βantitrypsin phenotypes. Using standard ophthalmologic criteria, we divided patients with anterior uveitis into acute, chronic (>3βmonth duration), bilatera