✦ LIBER ✦
Alpha-1-antitrypsin-deficient phenotype is not maintained by segregation distortion
✍ Scribed by B. K. Suarez; J. A. Pierce
- Publisher
- John Wiley and Sons
- Year
- 1983
- Tongue
- English
- Weight
- 401 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0002-9483
No coin nor oath required. For personal study only.
✦ Synopsis
Recent reports have suggested that the alpha-1-antitrypsin allele Piz, which in homozygotes results in severe deficiency of this important protease inhibitor, is maintained at a relatively high gene frequency through the mechanism of segregation distortion. We report here on 121 nuclear families selected because only one parent was segregating the Z allele. After correcting for ascertainment, no evidence of preferential transmission was observed in 278 informative offspring.