## Abstract Protein aggregation is the cause of several human diseases. Understanding the molecular mechanisms involved in protein aggregation requires knowledge of the kinetics and structures populated during the reaction. Arguably, the best structurally characterized misfolding reaction is that o
✦ LIBER ✦
Serpin polymerization and its role in disease—The molecular basis of α1-antitrypsin deficiency
✍ Scribed by Anja S. Knaupp; Stephen P. Bottomley
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 127 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.173
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Mechanism of α1 AT polymerization. See Serpin Polymerization and Its Role in Disease—the Molecular Basis of α~1~‐Antitrypsin Deficiency by Knaupp and Bottomley, pp. 1–5.
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alpha-1-antitrypsin; PiZZ, a1-ATZ phenotype; ER, endoplasmic acts with the target P 1 -P 1 residues of the reactive center loop, reticulum; MHC, major histocompatibility complex. the loop inserts further into the gap in the A sheet, generating From the: Departments of Pediatrics, Cell Biology, and