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Molecular pathogenesis of liver disease in α1-antitrypsin deficiency

✍ Scribed by J H Teckman; D Qu; D H Perlmutter

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
320 KB
Volume
24
Category
Article
ISSN
0270-9139

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✦ Synopsis

alpha-1-antitrypsin; PiZZ, a1-ATZ phenotype; ER, endoplasmic acts with the target P 1 -P 1 residues of the reactive center loop, reticulum; MHC, major histocompatibility complex.

the loop inserts further into the gap in the A sheet, generating From the: Departments of Pediatrics, Cell Biology, and Physiology, Washington Univera ''locked'' conformation and inactivating the cognate enzyme.

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