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Serotonin uptake in blood platelets of duchenne muscular dystrophy patients

✍ Scribed by Dr. Ramesh C. Arora; Herbert Y. Meltzer; Ralph W. Kuncl; Juliet Morgan; Louis Cohen

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 314 KB
Volume: 10
Category: Article
ISSN: 0148-639X
DOI: 10.1002/mus.880100413

No coin nor oath required. For personal study only.

✦ Synopsis

Serotonin (5-HT) uptake was studied in the blood platelets of 10 patients with Duchenne-type muscular dystrophy (DMD) and 7 age-matched controls. V,,, (maximum number of uptake sites) of platelet 5-HT uptake in the DMD patients was significantly less than that of the normal controls. There was no difference in the affinity for 5-HT (K,) between the two groups. There was a significant negative correlation between serum creatine kinase activity and K, of 5-HT uptake in blood platelets of these patients. However, no correlation was found between K, or V, , , and ambulatory status of DMD.

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