Serotonin transporter candidate gene studies in affective disorders and personality: promises and potential pitfalls
β Scribed by Greenberg, B D; McMahon, F J; Murphy, D L
- Book ID
- 110058926
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 48 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1359-4184
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The serotonin transporter is a compelling candidate gene to examine in bipolar and unipolar affective disorder, since drugs that specifically inhibit the serotonin transporter can successfully treat depression. Previous association studies of a VNTR polymorphism in intron 2 and a functional insertio
## Abstract Family, twin, and adoption studies show that psychiatric diseases including bipolar disorder (BP) and unipolar disorder (UP) have a substantial genetic component. For these illnesses, both positive and negative associations have been reported for two polymorphisms located in the seroton