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Serotonin antibodies in relation to immune activation in major depression

✍ Scribed by A. Sluzewska; W. Samborski; M. Sobieska; R. Klein; E. Bosmans; J. K. Rybakowski

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
126 KB
Volume
12
Category
Article
ISSN
0885-6222

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✦ Synopsis

Serum antibodies against serotonin and gangliosides, the serum concentration of serotonin in addition to indicators of immune activation, such as acute phase proteins (apps) and interleukin-6 (IL-6), were investigated in 20 major depressed patients and 32 normal controls. Antibody-positive sera against serotonin and gangliosides were increased in patients with major depression in comparison to normal controls. Serum concentrations of serotonin were signi®cantly lower in depressed patients. These changes were accompanied by acute phase response characterized by elevated concentration of apps and IL-6. Compared with patients showing positive response to antidepressant treatment, patients with treatment-resistant depression (TRD) had antibodies against serotonin and gangliosides that were twice as high, as well as a signi®cantly higher IL-6 concentration. The results suggest that alterations in the serotoninergic system may be related to immune activation in major depression and especially in treatment-resistant depression.

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