Antibodies against serotonin and gangliosides in patients with fibromyalgia and major depression

✍ Scribed by W. Samborski; A. Sluzewska; J. K. Lacki; M. Sobieska; R. Klein; S. Mackiewicz

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 75 KB
• Volume: 13
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/(sici)1099-1077(199803)13:2<137::aid-hup950>3.0.co;2-x

✦ Synopsis

Antibodies against serotonin and gangliosides in patients with ®bromyalgia and major depression

The ®bromyalgia syndrome (FMS) is a nonarticular disorder associated with disturbances in serotonin (5-HT) metabolism Samborski et al., 1996a,b). Moreover the psychological pro®les of these patients revealed elevated scores for depression and current or past psychiatric disturbances had been reported for up to 72 per cent of patients . Major depression (MD) is associated with low 5-HT concentration and with changes in immune reactivity. In this study we were interested in looking for the occurrence of autoimmune reactions against serotonin and related structures in ®bromyalgia and major depression. Twenty-six ®bromyalgia patients and 20 patients with major depression were included in the study. The control group consisted of 25 healthy individuals. None of the patients suered from any speci®c rheumatic disease or other disease associated with muscle pain. Blood samples were obtained at 7.30 am, centrifuged and the serum frozen at À808C until analysis. A standard ELISA