Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients
β Scribed by Taro Kishi; Tomoko Tsunoka; Masashi Ikeda; Tsuyoshi Kitajima; Kunihiro Kawashima; Tomo Okochi; Takenori Okumura; Yoshio Yamanouchi; Yoko Kinoshita; Hiroshi Ujike; Toshiya Inada; Mitsuhiko Yamada; Naohisa Uchimura; Ichiro Sora; Masaomi Iyo; Norio Ozaki; Nakao Iwata
- Book ID
- 116785370
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 149 KB
- Volume
- 58
- Category
- Article
- ISSN
- 0028-3908
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## Abstract Several lines of evidence suggest that oxidative stress plays a role in the mechanisms of action of methamphetamine (MAP) in the human brain. Given the role of glutathione __S__βtransferases (GSTs) in the protection against oxidative stress, genes encoding the GSTs have been considered
## Objectives We previously showed that the sirtuin 1 gene (__SIRT1__ gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)βinduced psychosis are similar to those of paranoid type schizophrenia and because n