No significant association between SIRT1 gene and methamphetamine-induced psychosis in the Japanese population

✍ Scribed by Taro Kishi; Yasuhisa Fukuo; Tomo Okochi; Tsuyoshi Kitajima; Hiroshi Ujike; Toshiya Inada; Mitsuhiko Yamada; Naohisa Uchimura; Ichiro Sora; Masaomi Iyo; Norio Ozaki; Christoph U. Correll; Nakao Iwata

• Book ID: 102261470
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 149 KB
• Volume: 26
• Category: Article
• ISSN: 0885-6222
• DOI: 10.1002/hup.1223

✦ Synopsis

Objectives

We previously showed that the sirtuin 1 gene (SIRT1 gene), one of the clock genes, was associated with schizophrenia in a Japanese patient population. Because the symptoms of methamphetamine (METH)‐induced psychosis are similar to those of paranoid type schizophrenia and because not every METH user develops psychosis, it is conceivable that METH‐induced psychosis and schizophrenia have common susceptibility genes. Therefore, we conducted an analysis of the association of SIRT1 gene with METH‐induced psychosis, hypothesizing a significant relationship.

Methods

This paper presents a case–control study of the SIRT1 gene in 515 Japanese individuals (197 with METH‐induced psychosis and 318 age‐matched and sex‐matched controls) with four tagging single nucleotide polymorphisms (rs12778366, rs2273773, rs4746720, and rs10997875), selected a priori using the HapMap database.

Results

rs10997875 (located in the 3′ flanking region) was associated with METH‐induced psychosis (unadjusted p~genotype~ = 0.0203). However, these results became non‐significant after Bonferroni correction (corrected p~genotype~ = 0.0812). In the all‐marker haplotype analysis, the SIRT1 gene was not associated with METH‐induced psychosis (p = 0.146).

Conclusion

Our findings suggest that SIRT1 gene does not contribute to the development of METH‐induced psychosis in the Japanese population. However, a replication study using larger samples should be conducted to obtain conclusive results. Copyright © 2011 John Wiley & Sons, Ltd.