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Serological activity of glycosphingolipids: Effect of chain length of the fatty acid residue in cytolipin H

✍ Scribed by L. Graf; M.M. Rapport


Publisher
Elsevier Science
Year
1974
Tongue
English
Weight
212 KB
Volume
13
Category
Article
ISSN
0009-3084

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✦ Synopsis


Serological reactions (complement-fixation) of a series of synthetic lactosyl dihydroceramides containing fatty acid residues with 2 to 18 carbon atoms were studied with two antisera reacting well with naturally occurring cytolipin H. The chain length of the fatty acid residue played an important role in activity of the hapten: molecules with 6 carbon atoms or less were unreactive, whereas molecules with 10 or more carbon atoms were maximally reactive.


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