Serine proteinases in human cutaneous mastocytosis
✍ Scribed by J. E. Fräki; N. M. Schechter; G. S. Lazarus
- Book ID
- 104767211
- Publisher
- Springer-Verlag
- Year
- 1986
- Tongue
- English
- Weight
- 324 KB
- Volume
- 278
- Category
- Article
- ISSN
- 0340-3696
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✦ Synopsis
The main chymotryptic and tryptic proteinases of human skin were found in high-salt extracts of human dermis. The levels of these enzymes were markedly increased in salt extracts of human cutaneous mastocytosis as compared to the levels found in extracts of involved skin from the same patients, human cutaneous hemangiomas, and normal human skin. These data suggest that the chymotryptic and tryptic proteinases of human skin are primarily of mast-cell origin.
📜 SIMILAR VOLUMES
## Background: Cutaneous mastocytosis is considered a relatively benign and indolent form of mast cell disease, which either ultimately regresses, remains stable or is only slowly progressive. previously, it has been purported that no more than 60% of adult patients with cutaneous mastocytosis will
## SUMMARY This is a retrospective review of the case files and clinical photographs of 173 children diagnosed with cutaneous mastocytosis by a dermatologist in an exclusively paediatric practice. Of the 98 males and 75 females, 51% had mastocytomas, 47% had urticaria pigmentosa and three patients