Bone marrow involvement in cutaneous mastocytosis

✍ Scribed by L.A. Fearfield; N. Francis; K. Henry; C. Costello; C.B. Bunker

• Book ID: 104459750
• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 603 KB
• Volume: 144
• Category: Article
• ISSN: 0007-0963
• DOI: 10.1046/j.1365-2133.2001.04084.x

✦ Synopsis

Background:

Cutaneous mastocytosis is considered a relatively benign and indolent form of mast cell disease, which either ultimately regresses, remains stable or is only slowly progressive. previously, it has been purported that no more than 60% of adult patients with cutaneous mastocytosis will have occult bone marrow involvement.

Objectives:

To investigate the frequency of bone marrow involvement in patients with mastocytosis but without systemic symptoms.

Methods:

Bone marrow aspirate and trephine biopsy were performed in 13 consecutive patients with cutaneous mastocytosis attending our department.

Results:

All but one of these patients had evidence of bone marrow involvement. bone marrow cytogenetic abnormalities have been found in patients with cutaneous mastocytosis: all our patients who were analysed showed a normal karyotype.

Conclusions:

Bone marrow involvement is common in adults with cutaneous mastocytosis.